A major shakeup in the Associated Press Top 25 rankings following last week’s upsets that saw five of the top-11 teams lose including No. 1 Alabama in a 40-35 loss to Vanderbilt as a 23-point favorite. The SEC is wide open, and Texas is back on top at No. 1 and tackles No. 18 Oklahoma in the Red River Rivalry. The Big Ten battle of No. 2 Ohio State at No. 3 Oregon also headlines the most bet games with four Top 25 matchups in Week 7 on Saturday, Oct. 12.

FanDuel is the official odds provider for The Associated Press, who selects voters for the AP Poll from sports reporters around the country who cover college football.

AP Top 25 Week 7 Matchups and Odds

College football odds from FanDuel Sportsbook refresh periodically and are subject to change, including on props and live betting. All times Eastern and betting favorites (-) listed.

Other receiving votes: Southern California 98, Nebraska 51, Navy 43, Army 33, Vanderbilt 26, Arkansas 17, Washington State 8, Iowa 8, Texas Tech 7, Syracuse 6, Washington 4, Louisville 4, Colorado 3, Kentucky 1.

Notable Line Moves Week 7

Circa Sports in Las Vegas opens the weekly college football lines on Sunday morning following each week’s NCAA football games. Here are the notable line moves with updates on FanDuel.

Ohio State at Oregon

Something has to give Saturday in Eugene as both No. 2 Ohio State and No. 3 Oregon are 5-0 including 2-0 in Big Ten play. The Buckeye’s and Ducks are two of nine undefeated Power Four schools. The new conference foes last played in the 2024 national championship won by the Buckeyes. Oregon and Ohio State both rank in the top-25 for both rushing and passing defense. The Ducks defense will be put to the test as Ohio State has scored 20 touchdowns in 21 red zone trips this season.

Oregon QB Dillon Gabriel opened the season as the Heisman favorite, and he’s now the fifth choice at +1400 odds, or 14/1. He’s passed for 1,449 yards and 11 touchdowns and leads the country with a 77.8 completion percentage. Ohio State QB Will Howard has thrown for 1,238 yards and 12 TD’s plus 4 rushing touchdowns.

The Buckeye’s have arguably the best set of RB’s and WR’s in the country. They have played a softer schedule, but the Buckeye’s defense has dominated holding opponents to a nation-low 203 yards per game while registering 17 sacks. Ohio State buried both Michigan State (38-7) and last week Iowa (35-7) limiting the Hawkeyes to just 224 total yards offense.

Pro Football Focus rates Ohio State as college football’s top team. The Buckeye’s lead the nation in overall team expected points added (EPA) per play , in EPA allowed, and EPA per play on offense.

The most watched and wagered game is set to kickoff at 7:30 p.m. ET on NBC. Ohio State is taking more money, and Buckeyes backers have wagered more money on the spread and moneyline than any other team for Week 7 at the leading online sportsbooks .

“Even on a loaded slate like this one, the action on Ohio State-Oregon stands out from the rest of the pack,” Fanatics Sportsbook staff reports. “If you combine spread and moneyline, Ohio State-Oregon has drawn over two times more handle than any other Week 7 game.”

Oregon, along with LSU are the most popular moneyline underdog bets this week.

Geoff Schwartz, an 8-year NFL offensive lineman who played right tackle at Oregon, chimed in on X with added insight on the Ohio State-Oregon matchup.

Ohio State (+290) is currently the favorite to win the national championship with Oregon at +1000, according to national championship odds at FanDuel Sportsbook. The winner will have a leg up towards the Big Ten title and new 12-team College Football Playoff while the loser remains in the mix for the CFP.

Penn State at USC

Another key Big Ten battle also has the road team favored with undefeated Penn State (5-0) at Southern Cal (3-2). Lincoln Riley is 41-4 at home as a head coach in his career, and now USC is a home underdog. The Trojans have played a far tougher schedule (No. 4) while the Nittany Lions SOS ranks No. 80. Bob Stoll of Dr. Bob Sports is a notable and respected handicapper who uses dozens of stats and categories in formulating models and picks.

Stoll notes that the Nittany Lions have moved the ball well on offense, averaging 7.3 yards per play against teams that would allow 6.0 yppl to an average offense. But Penn State has averaged just 24 points in two games against better than average defensive teams Illinois and UCLA, and USC’s defense (0.6 yppl better than average) rates about the same as those two defenses that held Penn State’s attack in check.

“The Nittany Lions should not be favored by 3 points or more in Los Angeles,” Stoll says.

Texas vs. Oklahoma

The Cotton Bowl in Dallas hosts the Red River Rivalry, or Showdown between new SEC rivals Oklahoma (4-1) and Texas (5-0). Oklahoma has won four of the last five meetings including last season 34-30 as a 5-point underdog when the Sooners entered No. 12 and Texas ranked No. 3 in the country.

FanDuel Research analysts pick Oklahoma (+14.5) to cover the spread in a higher scoring game (over 49.5). Sooners freshman QB Michael Hawkins Jr. is a Dallas native and plays in his fourth game while making his second start. He’ll be without a number of OU leading receivers on the injured list. Hawkins will become the first Oklahoma quarterback to start the Red River Showdown as a true freshman. Longhorns QB Quinn Ewers returns from an oblique injury suffered Sept. 14 vs. UT San Antonio. Texas is the largest favorite in the series since 2005, which was the last time the Longhorns won the national title. Texas ranks top-5 in yards per play offense, yards per game and points per game margin.

Ole Miss at LSU

Mixed picks on this SEC Saturday night showdown in Baton Rouge. Mississippi is No. 1 in yards per play and yards per game margin. LSU ranks No. 43 and No. 30 in those categories. However, Ole Miss is playing a 7th straight week and 3rd straight conference game while LSU is rested and ready off a bye. The Rebels and Tigers were both ranked top-20 last season as well and Ole Miss won a wild shootout over LSU, 55-49.

Dr. Bob Sports notes that LSU fits a greater than 63% ATS situation for teams coming off a win and a bye playing a conference home game and either an underdog or favorite up to 3 points. Additional parameters apply in a large sample size of more than 200 games, and LSU will catch another break if the nation’s leading receiver doesn’t play, Ole Miss senior Tre Harris (885 yards). He suffered a lower-leg injury in the first half of last week’s win over South Carolina. Harris is questionable to play, along with at least 10 other Rebels players on the injury list .

LSU’s strength has been its offense that has been 1.2 yards per play better than average (6.8 yppl against teams that would allow 5.6 yppl to an average team). Mississippi’s offense is better, as the Rebels have been 1.8 yppl better than average when they have the ball (7.9 yppl against 5 FBS teams that would allow 6.1 yppl to an average team.

Dr. Bob has a strong Opinion on Ole Miss noting the math model, but the strong situation favors LSU.

Playbook Sports adds an awesome angle that is 15-2 ATS favoring Oregon as a home underdog from game 6 forward if both teams own a 1.000 winning percentage and if the home ‘Dog scored 16 or more points in its last win.

No team plays a tougher 4-game stretch than LSU, who battles Ole Miss and then two road games at Arkansas and Texas A&M before a bye week to tackle Alabama.

More big game betting action ahead as college football’s biggest games draw the most watch and wager action.

You can bet on it.