The Pittsburgh Pirates and St. Louis Cardinals will meet on Tuesday at PNC Park, at 6:40 p.m. ET. Paul Skenes will start for Pittsburgh, trying to shut down Alec Burleson and company. The Cardinals are listed as +113 moneyline underdogs for this matchup with the favored Pirates (-134). Pittsburgh (-1.5) is the favorite on the run line. The matchup's over/under is set at 6.5 runs.

Here's everything you need from a betting perspective on the Pirates-Cardinals game, regarding the run line, moneyline and total, plus expert picks.

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Cardinals vs. Pirates Highlights | MLB on FOX

Pirates vs. Cardinals Game Information & Odds

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Cardinals vs. Pirates Highlights | MLB on FOX

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