Grizzly No. 399, a world-famous grizzly bear living in Grand Teton National Park in Wyoming, was killed by a vehicle. She was loved by tourists, biologists, and wildlife photographers for decades.

She died Tuesday night on a highway in Snake River Canyon south of Jackson, park officials said in a press release Wednesday. A yearling cub was with Grizzly No. 399 when she was struck, and while the cub is not believed to be hurt, its whereabouts are unknown at this time.

The driver was not injured in the collision.

"Wildlife vehicle collisions and conflict are unfortunate. We are thankful the driver is okay and understand the community is saddened to hear that grizzly bear 399 has died," said Wyoming Game and Fish Department Director Angi Bruce.

Grand Teton and U.S. Fish and Wildlife Service officials state that the circumstances of the crash were unclear, and they had no further information to release.

"People from around the world have followed grizzly bear 399 for several decades. At 28 years old, she was the oldest known reproducing female grizzly bear in the Greater Yellowstone Ecosystem," said Hilary Cooley, Grizzly Bear Recovery Coordinator for the U.S. Fish and Wildlife Service.