The Trump administration acted quickly on Monday to punish Harvard University after it refused to comply with a list of demands from the federal government that the school said were unlawful.

On Monday afternoon, Harvard became the first university to refuse to comply with the administration’s requirements, setting up a showdown between the federal government and the nation’s wealthiest university. By the evening, federal officials said they would freeze $2.2 billion in multiyear grants to Harvard, along with a $60 million contract.

Other universities have pushed back against the administration’s interference in higher education. But Harvard’s response, which called the Trump administration’s demands illegal, marked a major shift in tone for the nation’s most influential school, which has been criticized in recent weeks for capitulating to Trump administration pressure.

A letter the Trump administration sent to Harvard on Friday demanded that the university reduce the power of students and faculty members over the university’s affairs; report foreign students who commit conduct violations immediately to federal authorities; and bring in an outside party to ensure that each academic department is “viewpoint diverse,” among other steps. The administration did not define what it meant by viewpoint diversity, but it has generally referred to seeking a range of political views, including conservative perspectives.

A letter sent to Harvard on Friday by the Trump administration demanded that the university make a series of policy changes in order to continue to receive federal funding.

“No government — regardless of which party is in power — should dictate what private universities can teach, whom they can admit and hire, and which areas of study and inquiry they can pursue,” said Alan Garber, Harvard’s president, in a statement to the university on Monday.

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